Correction: Thioredoxin Glutathione Reductase from Schistosoma mansoni: An Essential Parasite Enzyme and a Key Drug Target

نویسندگان

  • Angela N Kuntz
  • Elisabeth Davioud-Charvet
  • Ahmed A Sayed
  • Lindsay L Califf
  • Jean Dessolin
  • Elias S. J Arnér
  • David L Williams
چکیده

In the supporting information section of this paper, the structures of oltipraz and safranin in Figure S1 were incorrect. The corrected fi gure may be found at Copyright: © 2007 Kuntz et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Thioredoxin Glutathione Reductase from Schistosoma mansoni: An Essential Parasite Enzyme and a Key Drug Target

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Schistosomiasis is a neglected tropical disease caused by a parasite Schistosoma mansoni and affects over 200 million annually. There is an urgent need to discover novel therapeutic options to control the disease with the recent emergence of drug resistance. The multifunctional protein, thioredoxin glutathione reductase (TGR), an essential enzyme for the survival of the pathogen in the redox en...

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Determining Potential Inhibitor(s) of Thioredoxin Glutathione Reductase, Key Enzyme of Schistosoma Mansoni Parasite

Schistosomiasis is a parasitic worm disease that affects more than 200 million people worldwide, and the drug praziquantel remains the only treatment. Recently there have been reports of patients showing signs of resistance to praziquantel. Consequently, there is an urgent need to develop a new drug to serve as an alternative to praziquantel. In this experiment, we will determine potential inhi...

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عنوان ژورنال:
  • PLoS Medicine

دوره 4  شماره 

صفحات  -

تاریخ انتشار 2007